What are protein interactions and protein networks?
Protein interactions occur when one or more proteins bind directly or indirectly to one another. These types of interactions occur in many cellular processes [1]. To mathematically represent protein interactions, you can create protein interaction networks. These interaction networks give a better visual understanding of the types of proteins that interact with your protein of interest and can be labeled by specific cellular process categories [2]. One program you can use to create these networks is STRING.
Discussion
The protein interaction network for FH in humans and zebrafish are very similar. Both of these organisms have some conserved proteins interactions with Fumarate and Malate, along side the FH protein. Understanding the other proteins involved in the conversion of Fumarate to Malate will give us knowledge about the mitochondrial homeostasis in kidney cells.
References:
[1] De Las Rivas, J., & Fontanillo, C. (2010, June 24). Protein-protein interactions essentials: key concepts to building and analyzing interactome networks. PLOS Computational Biology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891586/#pcbi.1000807-Mackay1
[2] Embl-Ebi. (n.d.). Protein-protein interaction networks | Network analysis of protein interaction data
https://www.ebi.ac.uk/training/online/courses/network-analysis-of-protein-interaction-data-an-introduction/protein-protein-interaction-networks/#:~:text=Protein%2Dprotein%20interaction%20networks%20(PPIN,they%20serve%20a%20specific%20function)
[2] Embl-Ebi. (n.d.). Protein-protein interaction networks | Network analysis of protein interaction data
https://www.ebi.ac.uk/training/online/courses/network-analysis-of-protein-interaction-data-an-introduction/protein-protein-interaction-networks/#:~:text=Protein%2Dprotein%20interaction%20networks%20(PPIN,they%20serve%20a%20specific%20function)
This web page was produced as an assignment for Genetics 564, a capstone course at UW-Madison.